Sleep and wakefulness are greatly influenced by various physiological and psychological factors. However, the neuronal elements responsible for organizing sleep-wake behavior in response to these factors are largely unknown. We have discovered that (1) neurotensin neurons in the lateral hypothalamus may play a crucial role in modulating sleep-wake states, and (2) neurons containing melanin-concentrating hormone in the posterior lateral hypothalamus play an integral role in rapid eye movement sleep regulation.
2, F Naganuma, Bandaru SS, Absi G Chee MJ and Vetrivelan R, ‘Melanin-concentrating hormone neurons promote rapid eye movement sleep independent of glutamate release.’, Brain struct Funct. 224(1):99-110 (2019)